Cannabidiol: an overview of some
pharmacological aspects

Mechoulam R, Parker LA, Gallily R.
Deportment of Medicinal Chemistry and Natural Products,
Hebrew University of Jerusalem, Israel.
J Clin Pharmacol 2002 Nov;42(11 Suppl):11S-19S


Over the past few years, considerable attention has focused on cannabidiol (CBD), a major nonpsychotropic constituent of cannabis. The authors present a review on the chemistry of CBD and discuss the anticonvulsive, antianxiety, antipsychotic, antinausea, and antirheumatoid arthritic properties of CBD. CBD does not bind to the known cannabinoid receptors, and its mechanism of action is yet unknown. It is possible that, in part at least, its effects are due to its recently discovered inhibition of anandamide uptake and hydrolysis and to its antioxidative effect.

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