Cellular and molecular mechanisms underlying learning
and memory impairments produced by cannabinoids

Sullivan JM Molecular Neurobiology Laboratory,
The Salk Institute,
La Jolla,
California 92037, USA.
Learn Mem 2000 May-Jun;7(3):132-9


Why does smoking marijuana impair learning and memory? Behavioral studies suggest that a disruption of normal hippocampal function contributes to these deficits. In vitro experiments find that cannabinoid receptor activation reduces neurotransmitter release below the levels required to trigger long-term changes in synaptic strength in the hippocampus. Cannabinoids reduce glutamate release through a G-protein-mediated inhibition of the calcium channels responsible for neurotransmitter release from hippocampal neurons. These mechanisms likely play a role in the learning and memory impairments produced by cannabinoids and by endogenous cannabinoid receptor ligands.

Just say know
Tolerant mice
Stoned as a newt?
The nectar of delight
Stoned chocaholics?
Rodent cannabis abuse
Cannabis and schizophrenia
Learning, memory and plasticity
Acute effects of cannabinoids on memory

01 02 03 04 05 06 07 08 09 10 11 12 13 14 15


Future Opioids
BLTC Research
Utopian Pharmacology
The Hedonistic Imperative
When Is It Best To Take Crack Cocaine?

swan image
The Good Drug Guide
The Responsible Parent's Guide
To Healthy Mood Boosters For All The Family