SR141716A reduces the reinforcing properties of heroin
but not heroin-induced increases in nucleus accumbens dopamine in rats

Pop E.
Caille S, Parsons LH.
Department of Neuropharmacology, CVN-7,
The Scripps Research Institute,
10550 North Torrey Pines Road,
La Jolla, CA 92037, USA.
Eur J Neurosci. 2003 Dec;18(11):3145-9


The present experiments tested the hypothesis that the selective CB1 receptor antagonist SR141716A alters heroin self-administration by attenuating heroin-induced increases in nucleus accumbens dopamine levels. SR141716A pretreatment dose-dependently (0.3-3 mg/kg, i.p.) reduced operant heroin self-administration by male Wistar rats under a fixed ratio schedule of reinforcement, and significantly lowered the breaking point of responding for heroin under a progressive ratio schedule of reinforcement. These observations are consistent with recent reports that CB1 receptor inactivation reduces the rewarding properties of opiates. Operant responding for water reinforcement by water-restricted rats was unaltered by these SR141716A doses. Microdialysis tests revealed that heroin self-administration significantly increases interstitial dopamine levels in the nucleus accumbens shell of vehicle-pretreated control rats. However, whereas SR141716A pretreatment dose-dependently reduced heroin self-administration, it did not alter the heroin-associated increase in nucleus accumbens dopamine. These findings suggest that the CB1 antagonist-induced attenuation of heroin reward does not involve dopaminergic mechanisms in the nucleus accumbens shell.

Just say know
Tolerant mice
Cannabis: effects
Forgetful rodents
Stoned as a newt?
Stoned chocaholics?
The nectar of delight
Cannabis and schizophrenia
Cannabinoids/Parkinson's disease
Rimonabant induces penile erections
A cure for chocoholics? Rimonabant (Acomplia)
Rimonabant (Acomplia), weight loss and dropout rates
Rimonabant produces modest yet sustained weight loss

01 02 03 04 05 06 07 08 09 10 11 12 13 14 15


Future Opioids
BLTC Research
Utopian Pharmacology
The Hedonistic Imperative
When Is It Best To Take Crack Cocaine?

swan image
The Good Drug Guide
The Responsible Parent's Guide
To Healthy Mood Boosters For All The Family