The psychoactive ingredient of marijuana
induces behavioural sensitization

Rubino T, Vigano D, Massi P, Parolaro D.
Department of Structural and Functional Biology,
University of Insubria, via Dunant 3,
21100 Varese, Italy.
Eur J Neurosci 2001 Sep;14(5):884-6


Here we describe, for the first time, the occurrence of behavioural sensitization after chronic exposure to Delta9-tetrahydrocannabinol. Rats were treated twice a day, for five days, with increasing doses (5, 10, 20, 40, 40 mg/kg i.p.) of Delta9-tetrahydrocannabinol or its vehicle and after 20 days of withdrawal, animals were challenged with 5 mg/kg (i.p.) of the drug and their behaviour was assessed. Contrary to the motor inhibition induced in control rats, challenge with Delta9-tetrahydrocannabinol in pre-exposed animals elicited a complex behavioural syndrome mainly characterized by oral stereotyped items. Due to the relevance of behavioural sensitization in drug-seeking behaviour that persists long after discontinuation of drug use, our findings suggest that cannabinoids could trigger neurobiological alteration not dissimilar from those observed with more harmful abused drugs.

Hemp oil
Hemp seeds
Swiss hemp
Just say know
Tolerant mice
Cannabis: effects
Forgetful rodents
Stoned as a newt?
Stoned chocaholics?
The nectar of delight
Cannabis and schizophrenia
Cannabinoids/Parkinson's disease

01 02 03 04 05 06 07 08 09 10 11 12 13 14 15


Future Opioids
BLTC Research
Utopian Pharmacology
The Hedonistic Imperative
When Is It Best To Take Crack Cocaine?

swan image
The Good Drug Guide
The Responsible Parent's Guide
To Healthy Mood Boosters For All The Family